3, April 2020
Rush for chloroquine as coronavirus tsunami looms 0
Despite loud appeals for caution, Africans are rushing to embrace chloroquine, the venerable anti-malaria drug touted as a possible treatment for coronavirus.
From hospitals in Senegal to pharmaceutical companies in South Africa and street sellers in Cameroon, chloroquine has fired hopes of a medicinal fix against a virus that is set to scythe through Africa’s poorly protected countries.
Chloroquine and derivatives such as hydroxychloroquine have been used for decades as cheap and safe drugs against malaria, although their effectiveness in this field is now undermined by growing parasite resistance.
Small-scale tests in China and France — either unpublished or outside the rigorous framework of mainstream drug trials — suggest that chloroquine reduces virus levels in people with coronavirus.
On March 24, President Donald Trump said chloroquine could be a “gift from God” — a comment that sparked strident criticism.
Health watchdogs have issued calls for caution until larger clinical trials are carried out, and there have been several recorded deaths from self-medication because of toxic side effects.
Despite this, in many settings across Africa, chloroquine has been placed in the front line against coronavirus.
Its rise stems partly from desperation, given Africa’s meager capacity to deal with a pandemic on the scale seen in Europe or the United States.
Burkina Faso, Cameroon and South Africa have swiftly authorized hospitals to treat virus patients with the drugs.
Around half of infected people in Senegal are already being prescribed hydroxychloroquine, Moussa Seydi, a professor at Dakar’s Fann Hospital, told AFP last Thursday.
Every patient who was recommended the drug accepted it, “with no exceptions,” he said.
In Democratic Republic of Congo, President Felix Tshisekedi last week declared it was “urgent” to produce chloroquine “in industrial quantities”.
South Africa has already said it will join a large-scale trial, and one of the country’s biggest pharmaceutical companies has promised to donate half a million pills to the health authorities.
Africa last in line?
Even if the effectiveness of the drugs against coronavirus remains for now unproven, concern about securing enough of them already runs deep.
Two decades ago, Africa, the continent worst hit by HIV, was last in line to get new antiretroviral AIDS drugs when the treatment emerged from the labs.
“If it turns out that chloroquine is effective, Africa, which imports most of its drugs, perhaps won’t be a priority for (the pharmaceutical) industry,” said Professor Yap Boum of Epicenter Africa, the research arm of the medical charity Doctors Without Borders (MSF).
France has already imposed a ban on exporting chloroquine and Morocco has requisitioned all stocks of the drug.
“You won’t find any in pharmacies in Yaounde, everyone is out of stock,” Boum said, referring to the Cameroonian capital.
“Local people have been buying it, apparently without prescription, which is dangerous.”
The Cameroonian government has officially asked health professionals “not to yield to the desire for profit” and to avoid prescribing chloroquine preventatively.
AFP correspondents report frantic demand in pharmacies in Abidjan, Ivory Coast’s economic hub, in the Angolan capital Luanda and also in Malawi — one of a handful of sub-Saharan nations where there are still no recorded cases of coronavirus.
The rush is a deep source of anxiety for people with the auto-immune disease called lupus, which is also treated with chloroquine.
In the Gabonese capital Libreville, Armelle Oyabi, head of an association of people with lupus, has been closely monitoring purchases at the only pharmacy left in the city that still has chloroquine.
“I check that the drug is being given to people who actually need it,” she said.
“If we can’t get this drug, we will not only be hit by lupus but also be more vulnerable to coronavirus.”
Chloroquine has been part of the medical toolkit from before World War II — it was developed in 1934 as a synthetic derivative of quinine.
Backstreet sales
Alice Desclaux, a doctor at the Institute of Development Research (IRD) in Senegal, said the risks from self-medication from chloroquine were largely rooted in illegal sales.
“Chloroquine has always been on sale informally in Africa,” she said.
“It’s still used to cause abortions” and even for attempted suicide, Desclaux said.
In one backstreet pharmacy in Douala, Cameroon’s economic hub, the manager said he had run out of stock.
For anyone who wished to order some, “careful, the price has gone up,” he said. A pill now changes hands for the equivalent of 71 US cents, four times more than a month ago.
The chloroquine craze is not just affecting the black market for drugs — it is also spurring the production of counterfeit medications.
Cameroon’s government has already issued a warning about fake chloroquine, samples of which have surfaced in health centers.
Source: AFP


















3, April 2020
Surge in coronavirus cases: UK government to build more emergency field hospitals 0
The UK government said Friday it was rushing to build more emergency field hospitals ahead of an expected surge in coronavirus cases, hours after recording a record 569 deaths from the disease.
Two new facilities will be built in Bristol in the west and Harrogate in the north to house up to 1,500 patients, the state-run National Health Service (NHS) said in a statement.
The announcement comes as a similar 4,000-bed facility in London — built in less than ten days — prepares to open Friday, and as criticism mounts over the government’s failure to provide screening, particularly for frontline healthcare workers.
“Further such hospitals will open next in Birmingham and Manchester, offering up to 3,000 beds between them,” the NHS statement added.
The health ministry announced a record 569 deaths from the virus in Britain in the 24 hours up to 1600 GMT on Wednesday — the largest single-day rise yet.
It followed 563 deaths over the previous corresponding period.
Prime Minister Boris Johnson has said Britain will “massively increase testing” for the COVID-19 virus following criticism of his initial light-touch approach to the outbreak.
Johnson has been in self-isolation “with mild symptoms” at his Downing Street official residence since announcing on March 27 that he had caught the virus.
Heir to the throne Prince Charles Thursday made his first public comments since coming out of self-quarantine after contracting the disease, telling the PA news agency the experience had been “strange, frustrating and often distressing”.
In a video message, he praised the “utter, selfless devotion to duty” of Britain’s health workers.
The country took part in another collective round of applause at 8:00 pm (2000 GMT) Thursday, with social media videos capturing cheers across its cities, towns and villages.
– Growing backlash –
Johnson is facing criticism even in normally supportive media outlets after officials revealed that just 2,000 out of about 500,000 NHS staff had been tested.
Health minister Matt Hancock said Thursday the government was “determined” to scale up tests across the board in the coming weeks, with a “goal of 100,000 tests per day by the end of this month”.
Hancock blamed global demand for swabs and reagents for the lack of tests, and said that some they had bought were faulty.
In order to meet the demand, the government said it would work with private firms such as Amazon and chemist Boots, and that three new “mega labs” would soon be online.
Testing for the general public has also been criticised as not widespread enough and is currently largely limited to hospital admissions of the most serious COVID-19 patients.
On Tuesday, 10,000 hospital patients and NHS staff were tested in England, well below the daily target of 25,000 and the 70,000 a day achieved in Germany, which has been used as a comparison.
Paul Nurse, chief executive of biomedical research centre the Francis Crick Institute, told the BBC Thursday that the government should summon “the Dunkirk spirit” and let “small ship” labs start screening for the killer disease.
So far, Public Health England (PHE), the body tasked with testing, has insisted all screening should be carried out centrally.
PHE medical director Professor Paul Cosford defended his organisation’s work.
“At the very outset we identified this, we got the tests in place, we designed the tests in our laboratories. We have played our part,” he told BBC radio.
Britain is currently in the second week of a three-week lockdown, with non-essential shops shut and the public asked to stay at home to try to limit the spread of the coronavirus.
The government has promised an enormous package of support for businesses and employees hit by the measures.
New government figures show 950,000 people applied for state welfare support known as universal credit in the last two weeks. It is available to the unemployed and those on low incomes.
With economic headwinds gathering pace, national carrier British Airways is also to temporarily lay off 28,000 staff, the union representing its workers announced Thursday.
Hancock, meanwhile, demanded that English Premier League footballers take a pay cut amid outrage at top flight clubs using a government furlough scheme for non-playing staff.
(Source: AFP)